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Hi, please mention what type of thalassemia is it. share reports for further clearance.

A healthy way to loose weight by diet and exercise is to maintain the weight loss to 2-8 pounds in a month so as you do not develop weakness. If you are loosing more than that please modify your regimen and if it you are still loosing it consult a doctor 

A healthy oxygen saturation level ranges between 95% and 100% . If a person's levels drop below this range, they may experience symptoms associated with a lack of oxygen, such as trouble breathing and confusion.