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Why don't we always find cholestasis in cirrhosis?
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In cholestasis, the movement of bile a digestive fluid which is produced by the liver is impaired at somewhere between the liver cells which produce bile and the first segment of the small intestine called duodenum. When bile is stopped from flowing, the pigment bilirubin which is a waste product formed due to breaking down of old or damaged red blood cells escapes into the bloodstream and accumulates. This binds with bile in the liver, moves through the bile ducts into the digestive tract, and is eliminated from the body. But the disease cirrhosis is due to the complication of the liver which is due to loss of liver cells and scarring of the liver. When liver cells are lost it is not possible that bile will be impaired between cells which produce bile.