2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
2049 Views 
0 Saved
3 Votes 1 Contributor2049 Views 0 SavedYou might also be interested in
Tramadol is harmful when taken in large doses but it can be harmful even in normal doses if you have an unhealthy liver. Tramadol is a medication used for the therapy of mild-to-moderate pain. Tramadol overdose can result in acute liver failure. If you have liver diseases or a history of liver disea....
The liver is the only organ in the living being which has the capability to regenerate after injury and surgeries. In mammals only mass of liver is replaced but not shape therefore the process of regeneration is compensatory growth. But in lower size species both shape and size can be replaced. The ....
Liver pain could be felt at the upper portion of the abdomen, on the right-hand side. This could be a sign of a severe disease. Liver pain can arise for various reasons. It is important to find out what is causing the pain and to get treatment to prevent irreversible damage. It can take several for....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.