2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
2054 Views 
0 Saved
3 Votes 1 Contributor2054 Views 0 SavedYou might also be interested in
List of diseases which affects liver: Cirrhosis - Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism Hepatitis Fatty liver Alpha 1-antitrypsin deficiency Primary biliary cholangit....
Tramadol is harmful when taken in large doses but it can be harmful even in normal doses if you have an unhealthy liver. Tramadol is a medication used for the therapy of mild-to-moderate pain. Tramadol overdose can result in acute liver failure. If you have liver diseases or a history of liver disea....
Dear All, Calculate MELD score based on the blood reports to understand the amount of damage Need reports to evaluate the patient condition Please share more symptoms Ascites tap needs to be performed if the fluid accumulation is more. It can cause bacterial infection Kindly talk to ou....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.