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Is the estrogen that can cause breast cancer the same estrogen that can cause uterine cancer, and vice versa?
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First of all, breast cancer isn't a death sentence: overall, about 60% of women survive breast cancer, and go on to live long and healthy lives. The percentage can be as high as 99%, depending on the particular type and stage of breast cancer. Stage 1, 2, 3 is easily curable by surgery followed b....
When you think about breast cancer, what do you think of? A young woman with nipple discharge? Probably not. And that's because we often associate a lump as a sign of breast cancer, as well as assuming it only affects older women. But what about the other symptoms? There are some lesser known ind....
Because they are derived from normal cells that have hormone receptors and the normal cells must respond to hormones in order to fulfil their function. A high proportion of breast cancers are Estrogen Receptor Positive. This means they have a large number of estrogen receptors, indicating that estro....
Suraj Kumar
Yes. In both cases, the reason is due to the activities of estrogen receptor (specifically Estrogen Receptor alpha), which is known to be a tumour promoter.
Endometrial cancer is a type of uterine cancer that involves the lining of the uterus. It is seen in women who take estrogen-only and still have a uterus. This is due to estrogen's effect on this lining, which builds up with prolonged estrogen stimulation. When this occurs, endometrial hyperplasia can result. Tamoxifen, an agent that can reduce the risk of developing breast cancer, can also cause endometrial cancer due to its similar effect on the endometrial lining.
Before menopause, the ovaries are the major source of the 2 main types of female hormones: estrogen and progesterone. The balance between these hormones changes during a woman's menstrual cycle each month. This produces a woman's monthly periods and keeps the endometrium healthy. A shift in the balance of these hormones toward more estrogen increases a woman's risk for developing endometrial cancer.