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Why don't we always find cholestasis in cirrhosis?
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Gluconeogenesis is a metabolic process that results in the generation of glucose from non-carbohydrate carbon substrates like lactate, glycerol, and glycogenic amino acids. Liver cells or hepatocytes have glucagon receptors. Glucagon can easily target the liver. When glucagon binds to the glucagon r....
The enlargement of Liver happens due to continuous transfusions without adequate chelation. If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelatio....
Anamika Sharma
In cholestasis, the movement of bile a digestive fluid which is produced by the liver is impaired at somewhere between the liver cells which produce bile and the first segment of the small intestine called duodenum. When bile is stopped from flowing, the pigment bilirubin which is a waste product formed due to breaking down of old or damaged red blood cells escapes into the bloodstream and accumulates. This binds with bile in the liver, moves through the bile ducts into the digestive tract, and is eliminated from the body. But the disease cirrhosis is due to the complication of the liver which is due to loss of liver cells and scarring of the liver. When liver cells are lost it is not possible that bile will be impaired between cells which produce bile.