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Why does the liver have fenestrated epithelium?
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Liver sinusoidal endothelial cells are constituted of a sinusoidal wall which is also called as endothelium or endothelial lining. The liver sinusoids are unique capillaries because of the presence of open pores or fenestrae lacking a diaphragm and a basal lamina underneath the endothelium, which differ from other capillaries in the body. The capillary endothelium plays a very important role in regulating the exchange of macromolecules, solutes, and fluid between the blood and the tissues surrounding it. In the presence of special transporting systems, the high permeability of capillary endothelium to macromolecules, solutes, and water are reflected represented by vesicles, channels, diaphragms, and fenestrae.