0
Is olaparib the only PARP inhibitor that has been approved?
- 1 people answered
0 Vote
1 Contributor
1788 Views 
0 Saved
0 Vote 1 Contributor1788 Views 0 SavedYou might also be interested in
Hello, please describe your problem in detail, then only we'll be able to provide you treatment costs. You can call us on +91-8010994994 and talk to our medical expert.
If you need a good cancer doctor in Kolkata, some experienced specialists are Dr. Chandrakanth MV, Dr. Rajib De, Dr. Tapti Sen, and Dr. Rajeev Sharan. They treat different types of cancer with the best care, including chemotherapy, radiation, and surgery. To find more doctors, check their availab....
Yes, but indirectly. Free radicals can damage DNA but the cells have their own reparative mechanisms. For free radicals to cause cancer, the following events need to happen:- 1. Damage in individual cells significant enough to overwhelm its reparative mechanisms. 2. Damage in such a way that even ....
Rahul Sharma
Yes, PARP inhibitors are relatively newer class of drugs and scientists have just begun to explore their functionality and usage in Cancer treatment. LYNPARZA is the first and only PARP inhibitor approved in 2 distinct settings: For the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, who are in complete or partial response to platinum-based chemotherapy. For the treatment of adult patients with suspected deleterious germline BRCA-mutated advanced ovarian cancer which has been treated with 3 or more prior lines of chemotherapy. Patients should be selected for therapy based on an FDA-approved companion diagnostic for LYNPARZA. Poly (ADP-ribose) Polymerase, or PARP, enzymes mediate DNA repair by transferring ADP-ribose units to preexisting ADP-ribose chains on proteins and to proteins. This ADP–ribosylation process recruits DNA repair enzymes, thereby maintaining genomic integrity. Inhibiting this process can lead to the accumulation of DNA damage and, ultimately, cell death.