What is the maximum plasma level of tamoxifen that can be achieved in breast cancer patients?
- 1 people answered
Edit Tags
Tags are used to find the best answers
You might also be interested in
Generally, women having their routine mammogram will receive a letter within one month with normal results. But if the doctor finds something suspicious, they’ll call you back, mostly within just 5 days, to take fresh pictures or other tests. Yes, that call may seem to be scary, but a suspicious fin....
Because they are derived from normal cells that have hormone receptors and the normal cells must respond to hormones in order to fulfil their function. A high proportion of breast cancers are Estrogen Receptor Positive. This means they have a large number of estrogen receptors, indicating that estro....
It’s very much unlikely. If the opposite armpit develops swollen nodes, it could be anything from an ingrown hair to a skin disease, to a swollen lymph node caused by an infection or even an injury down your arm. Many of these conditions require further testing or treatment. It is important to see y....
Credihealth is not a medical practitioner and does not provide medical advice. You should consult your doctor or with a healthcare professional before starting any diet, exercise, supplementation or medication program. Know More
লেখা:Dr. Nitika Sharma - BDS
পর্যালোচনা করা হয়েছে:Dr. Rakesh Kumar - MBBS, MS
Mithun Kumar
Tamoxifen is a highly effective endocrine treatment for breast cancer in the adjuvant and metastatic settings. Data from several large randomized clinical trials indicate that tamoxifen is also valuable in the prevention of breast cancer in women at high risk for the disease. However, not all women benefit from tamoxifen, and the side effect profiles vary considerably from patient to patient.
Tamoxifen treatment promotes significant changes both in the plasma concentration of an important marker associated with an increased risk of Cardio Vascular Disease (CVD) and in functional parameters of cardiac performance in women with breast cancer who have previously undergone chemotherapy. Previous studies had also confirmed the cardiotoxic effects of chemotherapy.
Chronic use of tamoxifen significantly reduces the plasma concentrations of CVD biomarkers (CRP, Apo B, and the Apo-B/Apo-A ratio) in women with breast cancer who underwent chemotherapy. Several study suggests the need for a careful cardiovascular evaluation and the medical monitoring of women with breast cancer to reduce the morbidity and mortality associated with cancer treatment complications.