0
Is olaparib the only PARP inhibitor that has been approved?
- 1 people answered
0 Vote
1 Contributor
1435 Views 
0 Saved
0 Vote 1 Contributor1435 Views 0 SavedYou might also be interested in
Yes...There are many stories with happy ending. Chemo is not the end of your life. Every day is a gift... that's what chemo reminds you. The majority of women who develop breast cancer around the world will not die of breast cancer. In fact, 8 out of 10 women who are diagnosed with breast cancer wil....
This is one of those 'beliefs' that pop up from time to time. There is no proven link between deodorant use and breast cancer. Any studies completed to date have not been adequate to show proof. There are lots of things that are believed to cause cancer and very few of them have been proven because ....
Only decades ago doctors and health professionals used to warn about the negative effects of having too much coffee because of the risk that caffeine was believed to have on your body. However, the last decade has shed so much light on the health benefits of coffee and its relationship with can....
Rahul Sharma
Yes, PARP inhibitors are relatively newer class of drugs and scientists have just begun to explore their functionality and usage in Cancer treatment. LYNPARZA is the first and only PARP inhibitor approved in 2 distinct settings: For the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, who are in complete or partial response to platinum-based chemotherapy. For the treatment of adult patients with suspected deleterious germline BRCA-mutated advanced ovarian cancer which has been treated with 3 or more prior lines of chemotherapy. Patients should be selected for therapy based on an FDA-approved companion diagnostic for LYNPARZA. Poly (ADP-ribose) Polymerase, or PARP, enzymes mediate DNA repair by transferring ADP-ribose units to preexisting ADP-ribose chains on proteins and to proteins. This ADP–ribosylation process recruits DNA repair enzymes, thereby maintaining genomic integrity. Inhibiting this process can lead to the accumulation of DNA damage and, ultimately, cell death.