What Is Doxinate Tablet Used For? Benefits, Dosage, and Side Effects Explained

Though pregnancy is a beautiful journey, morning sickness can make it a little bit challenging. But, do not worry, we have “Doxinate Tablet”, the best medicine formulated to relieve morning sickness, also known as vomiting and nausea, helping women to feel good and enjoy this special phase.

Let's explore the article and learn about the Doxinate tablet- its uses, benefits, side effects, and many more facts about it. 

Doxinate Tablet: A Brief Overview

Doxinate tablet is a potent prescription medicine that is commonly used for nausea and vomiting (also known as morning sickness) during pregnancy. It has an antihistamine action that helps manage these issues. In addition, it addresses hyperemesis gravidarum and provides great nourishment to the body. However, it should be used only under a doctor's guidance and as prescribed. It can bring some side effects that can be easily managed without any medical support. 

Doxinate Tablet Uses

Doxinate Tablet or Doxylamine-Pyridoxine Tablet is a prescription medicine used to treat conditions of feeling sick during pregnancy. This may include: 

• Nausea 

• Vomiting 

• Hyperemesis gravidarum (severe form of pregnancy-related nausea and vomiting)

Also, it is used to provide relief from nausea and vomiting after surgery and improve vitamin 6 deficiency. Moreover, it can reduce discomfort caused by digestive problems associated with pregnancy, making the pregnant women feel more comfortable.

Composition of Doxinate Tablet

It consists of 2 active ingredients:

• Doxylamine (an antihistamine): Blocks substances that cause nausea and vomiting.

• Pyridoxine (Vitamin B6):  Manages potential vitamin deficiencies that can contribute to nausea and vomiting.

Doxinate Tablet Dosage

Typically, the dosage depends on your medical condition, age, and body weight.

• In general, one tablet is recommended to take at bedtime.

• In severe cases, the dose is increased by 1 tablet in the morning and 1 in mid-afternoon. 

What to do in case of overdose and missed dose:

• Missed Dose: In case of a missed dose, take the dose when you remember. But, skip the dose if the time to take another dose is close. Avoid double-dosing.

• Overdose: If you experience doxinate overdose symptoms like lightheadedness, irregular heartbeat, dry mouth, enlarged pupils, restlessness, mental confusion, and sleepiness, seek emergency help immediately.

How to Take Doxinate?

Directions for use:

• Take a tablet by mouth on an empty stomach or as directed by your doctor.

• Swallow the tablet as a whole with a glass of water.

• Don’t break, crush, or chew tablets. 

Important Considerations:

• Do not take the dose more than the prescribed amount.

• Don’t stop using the medicine without a doctor’s guidance.

• Avoid taking it with food for better results.

• Do not use it for longer periods than suggested. 

• Take the tablet at the same time every day to maintain consistent blood levels. 

Benefits of Doxinate Tablets

The following are the benefits of taking Doxinate tablets: 

• Prevents Morning Sickness: A study says that doxylamine prevents nausea and vomiting by stopping the histaminergic signals from reaching the vomiting center in the brain.

• Provides Nutrition: Contains Pyridoxine, a Vitamin B6, which helps improve vitamin B6 levels in the body. 

• Supports Fetal Development: The vitamin B6 in this medicine supports the development of the brain and nervous system in the growing baby.

• Prevents Dehydration: Reduces the risk of excessive vomiting (seen in hyperemesis gravidarum), which retains fluids and maintains hydration levels.

• Prevents Nutrient Loss: By controlling vomiting, it aids in retaining vital minerals and vitamins from food.

How Do Doxylamine-Pyridoxine Tablets Work?

This is how doxinate tablets work to reduce morning sickness:

• Blocks Histamine: Doxylamine in Doxinate tablets is an antihistamine that blocks the signals of nausea and vomiting in the brain.

• Regulates Neurotransmitters: Pyridoxine aids in balancing brain chemicals that are involved in controlling nausea.

• Prevents Overstimulation of Vomiting Center: Doxylamine & Pyridoxine both calm down the brain area that triggers nausea.

The dual action of Doxylamine and Pyridoxine makes Doxinate tablets a safe and effective choice for preventing morning sickness during pregnancy.

Doxinate Tablet  Side Effects

The medicine is generally safe, well-tolerated, and intended for use only in pregnant women. If side effects occur, they subside after the body adjusts to the medicine. However, if they worsen or persist, seek medical help.

Common Side Effects:

• Feeling sleepy

• Drowsiness

• Dizziness

• Dry mouth

• Headache

• Blurred vision

• Constipation

Severe Side Effects:

In severe cases, some patients may experience allergic reactions that need immediate medical attention. The symptoms of allergic reactions are:

• Skin rash

• Itching

• Difficulty breathing

• Swelling of the face, lips, and tongue

Precautions While Taking Doxylamine-Pyridoxine Tablet

Consider these safety measures while taking Doxinate tablets:

• Hypersensitivity: Avoid this medicine if you have allergies to any of its ingredients to prevent further health risks.

• Other Current Medications: Inform the healthcare providers if you are taking pain relievers, sleeping medicines, or medications for cough, cold, or depression.

• Alcohol: Avoid mixing alcohol and Doxinate tablets as it may lead to dizziness, impaired thinking, difficulty concentrating, etc., which can cause accidents or fall risks.

• Pregnancy: Safe to use as it causes no harm to the fetus or pregnancy-related issues such as low birth weight or preterm childbirth.

• Breastfeeding: Probably unsafe during breastfeeding. Research reports that higher doses or long-term use of doxylamine may lower milk supply and cause drowsiness or other adverse effects on the nursing baby.

• Driving: As this medicine may decrease alertness, it may make you feel dizzy and sleepy or impact your vision. So, avoid driving.

• Chronic Liver Issues: People with chronic liver disorders should use the medicine with caution. Doctors may adjust the dose as needed.

• Use in Children: Not recommended to use in children under 18 years of age. So, always seek medical advice before using it. 

• Use in Older People: As elderly people are more prone to diseases or might be on other medications, use this medicine with caution only under the guidance of a doctor. 

Interactions of Doxinate Tablets

1. Interactions with other medicines

Doxinate may interact with other medications, which can worsen the side effects of Doxinate. So, always discuss them with your doctor. Those medicines include:

• Depression medications like monoamine oxidase inhibitors (MAOIs)

• Central nervous system depressants like barbiturates

• Pain medicines such as ibuprofen or aspirin

• Sleeping pills such as melatonin, zolpidem, and temazepam

2. Interactions with food items

Avoid taking Doxinate tablets with food as foods can slow down its absorption, which lowers the ability of the medicine to prevent nausea.

3. Interactions with pre-existing medical conditions

Inform your doctor about your existing medical conditions as they interact with Doxinate, which can worsen these conditions: 

• Asthma

• Narrow-angle glaucoma

• Increased eye pressure

• Blockage in the gut

• Stomach ulcers

• Depression

• Liver disease

• Peptic ulcer disease

Diet and Lifestyle Advice While Taking Doxinate Tablet

Follow these dietary and lifestyle tips to maximize the effects of doxinate tablets and minimize the risks of side effects:

• Consume small and more frequent meals: Prevents nausea and maintains energy levels.

• Avoid oily or spicy foods: These foods should be avoided as they trigger nausea, vomiting, and stomach discomfort.

• Stay hydrated: Drink a lot of water, soups, or coconut water to prevent the risk of dehydration.

• Get enough sleep: Prevents worsening of nausea, so aim to get 7-9 hours of quality sleep.

• Practice light physical activities: Go for a walk after eating food that can ease digestion.

• Avoid lying down immediately post-meals: This alleviates the risk of acid reflux and stomach discomfort.

Storage & Disposal of Doxinate Tablets

• Store the tablet below 25°C in a dry and clean place away from direct sunlight, heat, and moisture.

• Keep it away from your children and pets.

• Avoid its use once it expires.

• Do not use it if the packaging is damaged.

• Don't flush it on the toilet or throw it in the drain. Discard it properly when it expires.

Substitutes for Doxinate Tablet

If Doxinate does not suit you and does not give any results, try these substitutes. However, always consult the healthcare providers before using them:

Fact Box

Natural Alternatives to Doxinate Tablets

You can also choose natural alternatives to manage your morning sickness during pregnancy:

• Eat small and more frequent meals: Consume several smaller meals throughout the day instead of three large meals to prevent too empty or full stomach. 

• Consume bland or easy-to-digest foods: Examples are bananas, applesauce, rice, or plain yogurt, as they are gentle on the stomach. Avoid nausea-triggering foods like greasy, spicy, and fried foods.

• Stay hydrated: Drink a lot of water, ginger tea, or coconut water to manage dehydration, which is responsible for increasing nausea. 

• Ginger and lemon: Have ginger tea or lemon-flavored water to soothe nausea.

• Acupressure: Use acupressure wristbands to relieve nausea. 

• Rest and manage stress: Get adequate sleep and practice yoga and meditation to manage stress, as it can exacerbate nausea. 

Quick Tips

• Take Doxinate tablets as directed by the healthcare professionals, completing the dosage and duration.

• Common side effects may include fatigue, rashes, itching, and drowsiness. However, these effects are temporary and subside quickly.  

• If any of the side effects last or worsen, consult a doctor right away.

Final Thoughts

Doxinate tablets are the most effective medicines prescribed during pregnancy to treat nausea and vomiting. However, always use the dose as recommended to avoid the risk of side effects. Also, do not use them if you are allergic to its ingredients. If you experience any side effects that worsen or persist, consult your doctor; they may change the medication or stop its use. Make sure to always discuss your other medications and pre-existing health conditions with the providers to avoid further health complications.

Disclaimer: This information is intended for educational purposes only. Always consult a medical professional before using any medicine during pregnancy.