Entresto Side Effects, Dosages, Uses and Alternatives

Entresto is only the drug that is approved for heart failure. Entresto or Sacubitril and Valsartan help to prevent heart failure and reduce ejection fraction. The data showed it reduces hospitalization and saves the lives of people affected by chronic heart failure. It works on blocking the angiotensin ii receptor. Entresto contains two medications which are called Valsartan and Subcubitril, which is a Neprilysin receptor. It mainly blocks hormones that cause blood vessels to narrow down. This blog will discuss the entresto side effects, dosage, uses, and alternatives. Let's dive into the ocean of medicine. 

What could be the possible side effects of Entresto?

There are many side effects that you need to be concerned about. There are some given below: 

• Cough 
• Dizziness
• Lightheadedness 

If anyone has these symptoms worsening, immediately inform the doctor and ask for suitable treatment. To reduce dizziness and lightheadedness, you should slowly rise from lying to sitting.  This medication only doctors can prescribe because doctors first examine your health and risk factors associated with disease conditions. Though, there are no significant side effects associated with Entresto.  There are also severe Entresto Side Effects that may occur are: 

• Kidney problem 
• High potassium 
• Muscle weakness 
• Slow or irregular heartbeat 
• Fainting 

There can be allergic reactions because of the ingredients present in the drugs are:

• Rash 
• Itching 
• Swelling of face, mouth, tongue
• Severe dizziness 
• Trouble breathing 

Also, Read Hole in Heart - Causes, Symptoms & Treatment.

Adverse Drug Reactions 

• Blood and Lymphatic system disorders
• Immune system
• Metabolism and Nutrition disorders
• Nervous Systems
• Vascular Disorders
• Respiratory, thoracic, and mediastinal disorders
• Skin and Subcutaneous disorders
• Renal and urinary disorders

Entresto Dosage - 

There are differences between adult and pediatric doses. The normal adult dose for heart failure are:  Initial dose: 

• Sacubitril 49 mg
• Valsartan 51 mg

Both tablets should be taken orally twice a day.  Maintenance dose: Sacubitril 97 mg - Valsartan 103 mg orally twice a day  As tolerated, doctors may increase the target maintenance dose after 2 to 4 weeks. The initial amount of Sacubitril 24 mg - Valsartan 26mg is mainly recommended to take twice a day.  For children who are 40 kg, the starting dose is 1.6 mg combined with sacubitril and valsartan.  Read more about symptoms of Congenital Heart Defects.

Entresto oral uses - 

Entresto is an FDA-approved drug used for chronic heart failure in adults. The people who have heart failure with reduced ejection fraction. If the heart pumps less than or equal to 40% of the blood with each contraction, fluid in the lungs is built up. Research showed Entresto could prevent people from suffering from ejection fraction and reduce hospital or prevent heart failure. It is one of the most effective medicines for heart failure and improves ejection fraction. Entresto will depend on heart function and heart failure symptoms.  Entresto is given to that patient who suffers from other heart failure medications. It is recommended to take in place of an ACE inhibitor. 

Other Alternatives to Entresto - 

There are many alternatives to Entresto. You can take heart failure management medications that are listed below:

• ACE Inhibitors
  • Captopril
  • Fosinopril
  • Lisinopril
  • Perindopril
  • Quinapril
  • Ramipril
  • Trandolapril

• ARBs
  • Candesataran
  • Losartan

• Beta Blockers
  • Bisoprolol
  • Metoprolol Succinate

• Aldosterone Antagonists
  • Eplerenone

• Ivabradine
• SGLT2 Inhibitors
  • Jardiance

Also, read about: Symptoms of Heart Attack in Hindi.

Warnings and Precautions - 

There are many precautions and warnings you need to keep in mind if you are pregnant, then do not take Entresto. It can harm the fetus and may cause death. If you are suffering from high sugar levels, you should avoid taking Entresto and other medications as they may cause drug reactions. Therefore, always tell your doctor before taking any medications. What are the things you need to keep in mind before taking these medications: Suppose you are allergic to Savubitril or Valsartan, then do not take it; otherwise, it can cause severe allergic reactions.  ACE inhibitors like benazepril, captopril, or enalapril help you regulate cardiac functions. Other ARBs such as azilsartan, candesartan, and eprosartan enhance the heart's activity.  If you are suffering from these medications, then do always check with your doctor:: 

• Liver disease 
• Diabetes 
• Hereditary Angioedema 
• If you are on the low-salt diet 
• If you are dehydrated

Also, Read The Case of Fetus in Fetu: Human Inside a Human.

FAQs - 

Final Takeaway - 

The above blog has described the Entresto side effects, what the reaction to taking the pills should be, and what you need to tell the doctor. You can call an emergency doctor for immediate treatment if you feel the condition. If you need to contact a doctor, then you can. Though, an expert doctor is always required for the right treatment. You can also contact manipal hospital old airport road throughCredihealth for the same.  Heart disease is a life-threatening condition. Therefore, never avoid taking medicines on time. Health always comes first.