2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
3348 Views 
0 Saved
3 Votes 1 Contributor3348 Views 0 SavedYou might also be interested in
The liver is involved in metabolizing many toxins, including drugs and medications, chemicals, and natural substances. Liver disease causes the liver to function abnormally, as a result enhancing formation of toxins which results in inflammation. This further erodes stomach lining forming sores in t....
The liver is the only organ in the living being which has the capability to regenerate after injury and surgeries. In mammals only mass of liver is replaced but not shape therefore the process of regeneration is compensatory growth. But in lower size species both shape and size can be replaced. The ....
Low platelets count is one of the major symptoms of liver disease.Reduction of platelets which is also known as Thrombocytopenia occurs mainly due to reduced thrombopoietin. Thrombopoietin is actually a glycoprotein hormone generated by the liver & kidney that regulates the creation of platelets....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.