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Why does the liver enlarge in thalassemia?
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Edema is a swelling from fluid accumulation in body tissues. When parts of the body are affected with edemait is called edematous. Edema commonly affects the feet, ankles, legs, and hands which is peripheral edema. The swelling is the cause of the accumulation of excess fluid beneath the skin within....
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The main plasma lipid transport forms are triglyceride, free fatty acid and cholesteryl ester. Triglycerides are used in the making of some hormones and enzymes the body needs. It is also used in the manufacture of cell membranes in our bodies. Even if we limited our consumption of them, the liver w....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.